Methotrexate tablet is used alone or together with other medicines to treat several types of cancer, such as breast, head and neck, lung, blood (eg, acute lymphoblastic leukemia or ALL), bone, lymph node (eg, mycosis fungoides, relapsed or refractory non-Hodgkin lymphoma), or uterus cancer. The recommended starting dosage of Methotrexate Tablets is 10 mg/m 2 orally once weekly with escalation to achieve optimal response. Dosages of more than 30 mg/m 2 once weekly result in an increased risk of serious adverse reactions, including myelosuppression. It is known as a disease-modifying anti-rheumatic drug (DMARD), because it not only decreases the pain and swelling of arthritis, but it also can prevent damage to joints and long-term disability. Methotrexate comes either as pills or as a subcutaneous injection. Methotrexate tablets can cause embryo-fetal toxicity, including fetal death. For non- neoplastic diseases, methotrexate tablets are contraindicated in pregnancy. Methotrexate sodium is a type of chemotherapy called an antimetabolite, which is a drug that mimics a natural chemical and prevents its use in cells. It interferes with the way cells divide and function. Methotrexate is used to treat certain types of cancer of the breast, skin, head and neck, or lung. Learn about side effects, interactions and indications. Based on published reports of female infertility after methotrexate, advise females of reproductive potential that methotrexate can cause impairment of fertility and menstrual dysfunction. METHOTREXATE (METH oh TREX ate) treats inflammatory conditions such as arthritis and psoriasis. It works by decreasing inflammation, which can reduce pain and prevent long-term injury to the joints and skin. Overview: Methotrexate is used to treat certain types of arthritis, cancer, and severe psoriasis. Common side effects include nausea or vomiting, upset stomach, and mouth sores. Serious side. Methotrexate is used to treat certain types of cancer and rheumatoid arthritis. Learn about side effects, drug interactions, dosages, warnings, and more.